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Comments by JT Michcock...


 


    One of the most profound projects in the history of science is about to be completed.  I am speaking of the Human Genome Project, being conducted by the original group of governmental agencies  and pharmaceutical companies as well as Celera Genomics.  The effect of the completion of the project will not only affect the world of medicine, but also create social changes as the modifications take hold.  The net result will be a world-wide society with more clearly defined concepts of male and female.

UNLOCKING THE GENOME

Humans and all living creatures save the lowliest viruses are filled with a substance called deoxyribose nucleic acid (DNA).  DNA consists of a sugar molecule and an attached phosphate group.  DNA has four nitrogenous bases: two purines (adenine and guanine) and two pyrimidines (cytosine and thymine). 

 Those familiar with computer binary codes know that there are two possible code entries, 1 or 0.  In DNA, the potential codes are 4, A, G, C and T, making it more complex.  Movie goers might recognize these letters from the recent motion picture GATTACA whose dominant theme had to do with genetic engineering.

There are literally trillions of these base pairs within every cell.  What do they do?  On a very basic level, they code for proteins.  These proteins then combine to create structures and regulate the growth and maintenance of the organism.  In human beings, there are some 80,000 to 100,000 genes that code for all aspects of our physical being, including height, eye color and other familiar features.

Also being coded for, and only recently discovered, are various aspects of our behavior, intelligence and temperament.  It is sometimes a difficult prospect to grasp, but you are largely not a product of how you were raised but how you were born.  Language acquisition, for example, is a skill that is built into a person, including the development of neural pathways to allow children to build grammatical structures even when they have never heard the words used before.  D. Cohen, Strangers in the Nest, 77-80 (Wiley 1999).

There are also genes that determine how adventurous a person you may be, with the "thrill-seeking" gene being discovered in the mid 1990s as well as variables that promote anxiety. 

The reason Robbie Knieval followed in his father's footsteps has a lot to do with his genetic heritage as well as learned behaviors.

What the Human Genome Project seeks is a general road map of what genes exist in the human equation.  It is not entirely dissimilar to the computer programmer who reads lines of binary code to figure out the functions these instructions perform.  Once the road map is known, knowledge of function will follow quickly as different persons' genetic information is compared to the baseline.

With the advent of the Human Genome Project's completion, thoughts are already focused on how this knowledge will be used in the form of therapies.  Many technical obstacles need to be surmounted, but modification of behavior through genetic therapy is close enough to generate much discussion in the popular media. 

GENDER & GENETICS

One surprising absence from discussions is how gene therapy, once it does arrive, will shake out when it comes to the gender of the patient.   Quite simply, will the gender of the person make a difference between whether a person (or his parent) requests therapy?  A common sense analysis argues strongly that gender-based selection will be commonplace.  In a very real sense, this will make the existing differences between male and female all the greater.

In the physical arena, height is one such difference that already exists.  Men are, on average, taller than women.  Short guys have a hard time of it.  A recent Australian study revealed that shorter boys are more likely to fail in school than their taller classmates.  Interestingly, there is no like correlation with girls, their passage rates are unaffected by height. 

Envision a genetic surgeon coming into the room after a mother has given birth to meet with the parents.  With him is a chart that provides a read out of the child's genome with certain physical and behavioral estimates.  Meeting with the parents, he notes a strong likelihood that the child will develop colon cancer later in life.  The parents nod their approval at the doctor's suggestion that genetic therapy be used to lessen the cancer risk.

In discussing the child's other genetic properties, it emerges that the child is also likely grow to be between 5'6" to 5'8".  The child's temperament will also be introverted and passive.  The doctor wants to know if there are any additional modifications that should be made with the administration of the colon cancer reduction.

When it comes to these optional treatments, will the parents make a decision based upon the gender of the child?  Probably.  To say otherwise reveals more than a bit of self-deception.

With extroversion, parents with a boy will envision an agressive pusher, doing what he can to get things done.  With the same genetic make-up in a young lady, the parents will envision someone overly extroverted and likely to get into "trouble."

Much has been made lately about how the genders are becoming more similar.  Supposedly, women can compete in the same arena as men, and girls with boys.  I am still waiting for word that Dennis Rodman is attempting to enter the WNBA.  That should set a few tongues wagging.

Of course they can compete, but can they win at the highest levels?  Not too likely.  At least not in any sort of numbers close to equal.  The higher the status, the more men are attracted to the position.  This is not a "cultural" matter, although the culture provides the status to the position.  The male advantage exists regardless of the culture and this is entirely physiologically based.  In other words, patriarchy is in our genes.

I wrote above about computer programmers and the similarity between binary and DNA code.  This is coincidentally a good starting point to discuss how status attracts men. 

Here are some figures to contemplate.  In 1976, women comprised some 45.9% of the bachelor degree recipients in computer science programs.  Now that professions in computer sciences have developed a certain cachet, women were only 28.5% of those graduates in 1994.

Men and women both seek status.  The difference is that men will pursue that status with more determination and sacrifice more readily their health and safety to achieve.  The numbers tell it all.   One 1994 MIT survey found that a lot of women were dissuaded from entering computer science programs was because it was "too competitive." 

FUTURE BODIES

In the future, the abilities of men and women will grow greater as genetic manipulation becomes commonplace.  With genetic engineering being introduced on a wide scale in the upcoming years, these innate differences will become more disparate.

Will there be groups that disavow gender based genetic discrimination?  Certainly.  For a while, groups may be able to impose certain restrictions at the outset, but that is not likely to last very long.  Even now, arguments are being raised about genetic "enhancements" in various scholarly publications.  Medical organizations such as National Society of Genetic Counselors are opposed to cloning and genetic testing for sex selection.  These "enhancements" are differentiated from "corrective" measures.

This raises the question: who the hell are the National Society of Genetic Counselors?  Since when does *any* organized group have the right to dictate what parents should determine are "corrective" measures versus those that are "enhancements."  In a world where modifying a child's eyesight from 20/40 to 20/20 is a prohibited enhancement while changing it from 20/100 to 20/40 is an appropriate corrective measure, the distinction becomes arbitrary and meaningless.

 It is profoundly upsetting to see groups and organizations trying to enforce by legal mandate to parents how their children should be raised.  One has to question what business these people have meddling in the first place.  Are they really so omniscient and wise that their choices for our children's futures be entrusted to their dictatorial embrace?

Governmentally enforced eugenics policies were once the rage of the Third Reich.  A governmental policy that seeks to enforce rules controlling individual genetic choices is no different regardless of the stated motivations for the controls.

PARENTS AND CHILDREN

There is going to be a battle ahead with respect to what sort of genetic engineering will be done on human beings.  The intellectuals who attend seminars and debate these topics ad nauseam will continue to do so.  But the people who will have to live with these decisions, namely the parents, are the ones who will ultimately be asked to make the call.

It is a safe bet that where children are concerned, it is not likely that parents will be reluctant to introduce wide scale changes.  After all, they are parents and for the most part seek to do the best by their children.  Anyone looking for The Island of Doctor Moreau to pop up in the  neighborhood schoolyard will be disappointed.

Certainly, there will be exceptions to the general rule.  Some parents will want aggressive girls and more sensitive boys.  There will also be parents who name their kids "Rumer" and "Scout."  Fortunately, this is not most people.

Most of these exceptions will likely emerge from the western liberal intelligentsia.  One thing to recall when discussing genetic modifications is that the Caucasian population in post-industrial nations is only a small portion of the world.  Even here, the sophisticated, brie-loving urban dwellers are far outnumbered by the bowling, suburban NASCAR fans (or soccer fans in other nations). 

It would be a prescription for disaster for any nation to try to promote creation of a cowed population of young men.  Sooner or later, these men will be called upon to do battle with far more aggressive counterparts in the third world.  Such utter stupidity in making these men more "sensitive" will be rewarded with the destruction of the society making such modifications.

BOTTOM LINE

Parents desire that their kids be happy.  In a world where boys are becoming taller, more muscular and extroverted while girls are becoming shorter overall, rounder and more introverted, the numbers will direct that parents go with the flow.  Man is a social animal and needs the approval, attention and interaction of others.  In a sense, Jean-Paul Sarte got it precisely wrong; heaven is other people.

As social animals, it is insufficient for people to think of themselves in isolation.  While individuality is a key component to a healthy life, so to is a sense of belonging.  One of the key areas where people require a sense of meaning is from their gender.

Stereotypes that in past times existed as to what comprises the "ideals" of  male and female will soon become the norm.  In that future, guided by the Human Genome Project, and the therapies that will become more commonplace, the differences between male and female will become more apparent, even more so than they are already. 
 

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